SRSF3
SRSF3 (Serine/arginine-rich splicing factor 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognises and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SRSF3 (Serine/arginine-rich splicing factor 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
SRSF3 (Serine/arginine-rich splicing factor 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing.
- 3 · How drugs use it
No product in this corpus aims at SRSF3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10785 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P84103 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000112081 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognises and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Location: Nucleus; Nucleus speckle; Cytoplasm (UniProt). Locus 6p21.31-p21.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SRSF3" OR ABSTRACT:"SRSF3" OR TITLE:"serine and arginine rich splicing factor 3" OR ABSTRACT:"serine and arginine rich splicing factor 3" OR TITLE:"Serine/arginine-rich splicing factor 3" OR ABSTRACT:"Serine/arginine-rich splicing factor 3" OR TITLE:"SRp20" OR ABSTRACT:"SRp20" OR TITLE:"SFRS3" OR ABSTRACT:"SFRS3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SRSF3, not a curated reading list.