TBPL1
TBPL1 (TATA box-binding protein-like 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TBPL1 (TATA box-binding protein-like 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
TBPL1 (TATA box-binding protein-like 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1.
- 3 · How drugs use it
No product in this corpus aims at TBPL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:11589 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62380 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000028839 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. Location: Cytoplasm; Nucleus (UniProt). Locus 6q23.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TBPL1" OR ABSTRACT:"TBPL1" OR TITLE:"TATA-box binding protein like 1" OR ABSTRACT:"TATA-box binding protein like 1" OR TITLE:"TATA box-binding protein-like 1" OR ABSTRACT:"TATA box-binding protein-like 1" OR TITLE:"TRF2" OR ABSTRACT:"TRF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBPL1, not a curated reading list.