TF
TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Overview
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
- 1 · What it is
TF (Serotransferrin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
- 2 · What goes wrong in cancer
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
- 3 · How drugs use it
No product in this corpus aims at TF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11740 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02787 (protein name, function text, keywords and locations (REST API)); CIViC gene TF (1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0))
Biology
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilisation. Serum transferrin may also have a further role in stimulating cell proliferation. Location: Secreted (UniProt). Locus 3q22.1 (HGNC).
- Melanoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TF" OR ABSTRACT:"TF" OR TITLE:"transferrin" OR ABSTRACT:"transferrin" OR TITLE:"Serotransferrin" OR ABSTRACT:"Serotransferrin" OR TITLE:"PRO1557" OR ABSTRACT:"PRO1557" OR TITLE:"PRO2086" OR ABSTRACT:"PRO2086") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TF, not a curated reading list.