TLX3
TLX3 (T-cell leukaemia homeobox protein 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3".
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.16, somatic mutation 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TLX3 (T-cell leukaemia homeobox protein 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
TLX3 (T-cell leukaemia homeobox protein 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3". Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at TLX3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:13532 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43711 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164438 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3". Location: Nucleus (UniProt). Locus 5q35.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TLX3" OR ABSTRACT:"TLX3" OR TITLE:"T cell leukemia homeobox 3" OR ABSTRACT:"T cell leukemia homeobox 3" OR TITLE:"T-cell leukemia homeobox protein 3" OR ABSTRACT:"T-cell leukemia homeobox protein 3" OR TITLE:"HOX11L2" OR ABSTRACT:"HOX11L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLX3, not a curated reading list.