TMEM17
TMEM17 (Transmembrane protein 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signalling.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.68).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TMEM17 (Transmembrane protein 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
TMEM17 (Transmembrane protein 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
- 3 · How drugs use it
No product in this corpus aims at TMEM17 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:26623 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86X19 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186889 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0))
Biology
Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signalling. Location: Cell projection, cilium membrane (UniProt). Locus 2p15 (HGNC).
- Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TMEM17" OR ABSTRACT:"TMEM17" OR TITLE:"transmembrane protein 17" OR ABSTRACT:"transmembrane protein 17" OR TITLE:"Transmembrane protein 17" OR ABSTRACT:"Transmembrane protein 17" OR TITLE:"FLJ34583" OR ABSTRACT:"FLJ34583") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TMEM17, not a curated reading list.