TOE1
TOE1 (Target of EGR1 protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.73, affected pathway 0.25, genetic association 0.77).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TOE1 (Target of EGR1 protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
TOE1 (Target of EGR1 protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression.
- 3 · How drugs use it
No product in this corpus aims at TOE1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:15954 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96GM8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132773 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing. Location: Nucleus, nucleolus; Nucleus speckle (UniProt). Locus 1p34.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TOE1" OR ABSTRACT:"TOE1" OR TITLE:"target of EGR1, exonuclease" OR ABSTRACT:"target of EGR1, exonuclease" OR TITLE:"Target of EGR1 protein 1" OR ABSTRACT:"Target of EGR1 protein 1" OR TITLE:"hCaf1z" OR ABSTRACT:"hCaf1z" OR TITLE:"TOE-1" OR ABSTRACT:"TOE-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TOE1, not a curated reading list.