TOP2B
TOP2B (DNA topoisomerase 2-beta) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Neuroendocrine tumours, Breast cancer and 1 more.
Overview
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.93, animal model 0.39, genetic association 0.45, clinical 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TOP2B (DNA topoisomerase 2-beta) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Neuroendocrine tumours, Breast cancer and 1 more.
- 1 · What it is
TOP2B (DNA topoisomerase 2-beta) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Neuroendocrine tumours, Breast cancer and 1 more.
- 2 · What goes wrong in cancer
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
- 3 · How drugs use it
No product in this corpus aims at TOP2B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:11990 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q02880 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000077097 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: small cell lung carcinoma 0.56, neuroendocrine neoplasm 0.57, breast cancer 0.55, lung cancer 0.58 (GraphQL API, CC0))
Biology
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. Location: Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus (UniProt). Locus 3p24.2 (HGNC).
- Lung cancer: Open Targets association 0.58 with lung cancer (MONDO_0008903)
- Neuroendocrine tumours: Open Targets association 0.57 with neuroendocrine neoplasm (MONDO_0019496)
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)
- Small-cell lung cancer: Open Targets association 0.56 with small cell lung carcinoma (MONDO_0008433)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TOP2B" OR ABSTRACT:"TOP2B" OR TITLE:"DNA topoisomerase II beta" OR ABSTRACT:"DNA topoisomerase II beta" OR TITLE:"DNA topoisomerase 2-beta" OR ABSTRACT:"DNA topoisomerase 2-beta" OR TITLE:"top2beta" OR ABSTRACT:"top2beta" OR TITLE:"TOPIIB" OR ABSTRACT:"TOPIIB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TOP2B, not a curated reading list.
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