TPM3
TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer.
Overview
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon.
Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.76, genetic association 0.09, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer.
- 1 · What it is
TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.
- 3 · How drugs use it
No product in this corpus aims at TPM3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12012 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P06753 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143549 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.50, colorectal cancer 0.50, lung cancer 0.52 (GraphQL API, CC0))
Biology
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1q21.3 (HGNC).
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
- Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)
- Non-small-cell lung cancer: Open Targets association 0.50 with non-small cell lung carcinoma (MONDO_0005233)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TPM3" OR ABSTRACT:"TPM3" OR TITLE:"tropomyosin 3" OR ABSTRACT:"tropomyosin 3" OR TITLE:"Tropomyosin alpha-3 chain" OR ABSTRACT:"Tropomyosin alpha-3 chain" OR TITLE:"NEM1" OR ABSTRACT:"NEM1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPM3, not a curated reading list.
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