TRPS1
TRPS1 (Zinc finger transcription factor Trps1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.25, animal model 0.57, genetic association 0.69).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TRPS1 (Zinc finger transcription factor Trps1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
TRPS1 (Zinc finger transcription factor Trps1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development.
- 3 · How drugs use it
No product in this corpus aims at TRPS1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:12340 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UHF7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104447 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: breast cancer 0.53 (GraphQL API, CC0))
Biology
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Location: Nucleus (UniProt). Locus 8q23.3 (HGNC).
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TRPS1" OR ABSTRACT:"TRPS1" OR TITLE:"transcriptional repressor GATA binding 1" OR ABSTRACT:"transcriptional repressor GATA binding 1" OR TITLE:"Zinc finger transcription factor Trps1" OR ABSTRACT:"Zinc finger transcription factor Trps1" OR TITLE:"GC79" OR ABSTRACT:"GC79") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRPS1, not a curated reading list.