TSPYL1
TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Overview
UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1".
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Abiraterone and Prednisone.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 1 · What it is
TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1". Location: Nucleus, nucleolus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at TSPYL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12382 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H0U9 (protein name, function text, keywords and locations (REST API)); CIViC gene TSPYL1 (2 evidence items, 0 assertions, 2 variants; diseases: Prostate Cancer (GraphQL API, CC0))
Biology
UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1". Location: Nucleus, nucleolus (UniProt). Locus 6q22.1 (HGNC).
- Prostate cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TSPYL1" OR ABSTRACT:"TSPYL1" OR TITLE:"TSPY like 1" OR ABSTRACT:"TSPY like 1" OR TITLE:"Testis-specific Y-encoded-like protein 1" OR ABSTRACT:"Testis-specific Y-encoded-like protein 1" OR TITLE:"TSPYL" OR ABSTRACT:"TSPYL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TSPYL1, not a curated reading list.