TYMP
TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.
Overview
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.46, clinical 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.
- 1 · What it is
TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
- 3 · How drugs use it
No product in this corpus aims at TYMP yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:3148 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P19971 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000025708 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0))
Biology
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilised as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Locus 22q13.33 (HGNC).
- Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TYMP" OR ABSTRACT:"TYMP" OR TITLE:"thymidine phosphorylase" OR ABSTRACT:"thymidine phosphorylase" OR TITLE:"Thymidine phosphorylase" OR ABSTRACT:"Thymidine phosphorylase" OR TITLE:"MNGIE" OR ABSTRACT:"MNGIE" OR TITLE:"ECGF1" OR ABSTRACT:"ECGF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYMP, not a curated reading list.