VPS37A
VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Overview
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
- 1 · What it is
VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
- 2 · What goes wrong in cancer
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
- 3 · How drugs use it
No product in this corpus aims at VPS37A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:24928 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NEZ2 (protein name, function text, keywords and locations (REST API)); CIViC gene VPS37A (1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
Biology
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Location: Late endosome membrane; Nucleus (UniProt). Locus 8p22 (HGNC).
- Ovarian cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"VPS37A" OR ABSTRACT:"VPS37A" OR TITLE:"VPS37A subunit of ESCRT-I" OR ABSTRACT:"VPS37A subunit of ESCRT-I" OR TITLE:"Vacuolar protein sorting-associated protein 37A" OR ABSTRACT:"Vacuolar protein sorting-associated protein 37A" OR TITLE:"FLJ32642" OR ABSTRACT:"FLJ32642" OR TITLE:"HCRP1" OR ABSTRACT:"HCRP1" OR TITLE:"SPG53" OR ABSTRACT:"SPG53") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VPS37A, not a curated reading list.