WRAP53
WRAP53 (Telomerase Cajal body protein 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
RNA chaperone that plays a key role in telomere maintenance and RNA localisation to Cajal bodies. Specifically recognises and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.24, genetic literature 0.76).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · WRAP53 (Telomerase Cajal body protein 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
WRAP53 (Telomerase Cajal body protein 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
RNA chaperone that plays a key role in telomere maintenance and RNA localisation to Cajal bodies.
- 3 · How drugs use it
No product in this corpus aims at WRAP53 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:25522 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BUR4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141499 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
RNA chaperone that plays a key role in telomere maintenance and RNA localisation to Cajal bodies. Specifically recognises and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. In addition, also controls telomerase holoenzyme complex localisation to Cajal body. Location: Nucleus, Cajal body; Chromosome, telomere; Chromosome (UniProt). Locus 17p13.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"WRAP53" OR ABSTRACT:"WRAP53" OR TITLE:"WD repeat containing antisense to TP53" OR ABSTRACT:"WD repeat containing antisense to TP53" OR TITLE:"Telomerase Cajal body protein 1" OR ABSTRACT:"Telomerase Cajal body protein 1" OR TITLE:"FLJ10385" OR ABSTRACT:"FLJ10385" OR TITLE:"TCAB1" OR ABSTRACT:"TCAB1" OR TITLE:"WDR79" OR ABSTRACT:"WDR79") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WRAP53, not a curated reading list.