XRCC1
XRCC1 (DNA repair protein XRCC1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer and Non-small-cell lung cancer.
Overview
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognises and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.
CIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Docetaxel, Gemcitabine, Carboplatin and Vinorelbine and others. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.78).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · XRCC1 (DNA repair protein XRCC1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer and Non-small-cell lung cancer.
- 1 · What it is
XRCC1 (DNA repair protein XRCC1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes.
- 3 · How drugs use it
No product in this corpus aims at XRCC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12828 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P18887 (protein name, function text, keywords and locations (REST API)); CIViC gene XRCC1 (3 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Cervical Cancer (GraphQL API, CC0)); Open Targets ENSG00000073050 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognises and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity. Location: Nucleus; Chromosome (UniProt). Locus 19q13.31 (HGNC).
- Cervical cancer: CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"XRCC1" OR ABSTRACT:"XRCC1" OR TITLE:"X-ray repair cross complementing 1" OR ABSTRACT:"X-ray repair cross complementing 1" OR TITLE:"DNA repair protein XRCC1" OR ABSTRACT:"DNA repair protein XRCC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about XRCC1, not a curated reading list.