YWHAB
YWHAB (14-3-3 protein beta/alpha) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.97, animal model 0.30, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · YWHAB (14-3-3 protein beta/alpha) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
YWHAB (14-3-3 protein beta/alpha) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
- 3 · How drugs use it
No product in this corpus aims at YWHAB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12849 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31946 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166913 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonises its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signalling cascades that mediate activation of MAP kinases via AKAP13. Location: Cytoplasm; Melanosome; Vacuole membrane (UniProt). Locus 20q13.12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"YWHAB" OR ABSTRACT:"YWHAB" OR TITLE:"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta" OR ABSTRACT:"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta" OR TITLE:"14-3-3 protein beta/alpha" OR ABSTRACT:"14-3-3 protein beta/alpha" OR TITLE:"YWHAA" OR ABSTRACT:"YWHAA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about YWHAB, not a curated reading list.