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Chaparral is a desert shrub long used as a folk cancer remedy and an ingredient of black salve. A phase 2 trial found it ineffective against cancer, and it has caused severe liver damage, some cases needing a liver transplant.
Chaparral (Larrea tridentata) grows in the deserts of Mexico and the south-west United States and was used by Native Americans for skin sores, diabetes, cancer and other conditions. Memorial Sloan Kettering's About Herbs summary states that a phase II clinical trial found chaparral ineffective as an anticancer agent. Its active compound, nordihydroguaiaretic acid (NDGA), has anticancer effects in the laboratory, and a pilot study in relapsed prostate cancer reported tolerability with changes in PSA doubling time but raised liver enzymes in some patients. MSK warns that chaparral and products containing it have been associated with severe hepatotoxicity, some cases requiring liver transplantation, and lists fatigue, jaundice and cirrhosis among reported reactions. The US FDA removed NDGA from its list of substances generally recognised as safe, and a topical NDGA cream was withdrawn in 1996. Chaparral is an ingredient of black salve.
NDGA is an antioxidant lignan that inhibits lipoxygenase and growth-factor receptors in cell culture; it is also directly toxic to the liver.
Query for this technology: (TITLE:"Chaparral" OR ABSTRACT:"Chaparral" OR TITLE:"creosote bush" OR ABSTRACT:"creosote bush") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Chaparral (creosote bush), not a curated reading list.
Shares Black salve and other escharotic pastes, Alternative medicine used instead of standard treatment, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Evidence-based integrative oncology and the tags complementary, supportive-care.
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Shares Alternative medicine used instead of standard treatment, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Alternative medicine used instead of standard treatment, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Alternative medicine used instead of standard treatment, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Alternative medicine used instead of standard treatment, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Alternative medicine used instead of standard treatment, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Alternative medicine used instead of standard treatment, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
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