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Keeping food going down the throat during radiotherapy, and doing swallowing exercises through it, both independently predict being back on a normal diet afterwards. In 595 patients, those who kept eating were twice as likely to be on solid food at three to six months and those who exercised were 2.9 times as likely.
Radiotherapy to the throat causes fibrosis of the swallowing muscles, loss of saliva and loss of sensation. The muscles that are not used during treatment atrophy faster. The clinical doctrine that follows is called use it or lose it, and it has been tested twice, by the same group, retrospectively and then prospectively.
The retrospective study. Hutcheson and colleagues analysed 497 patients treated with definitive radiotherapy or chemoradiotherapy for pharyngeal cancer. At the end of treatment 26 per cent had no oral intake and 74 per cent had kept some; 58 per cent reported adherence to swallowing exercises. Both maintenance of oral intake and exercise adherence were independently associated with better long-term diet and shorter gastrostomy dependence, in models adjusted for tumour and treatment burden. Their conclusion is quotable: "Patients who either eat or exercise fare better than those who do neither. Patients who both eat and exercise have the highest rate of return to a regular diet and shortest duration of gastrostomy dependence."
The prospective validation. The same analysis was repeated on a prospective registry of 595 patients with oropharyngeal cancer, using validated clinician-graded and patient-reported measures. At the end of radiotherapy 9 per cent were taking nothing by mouth, 19 per cent partial and 71 per cent full, and 57 per cent reported exercise adherence. After adjustment, return to a solid diet at three to six months was independently associated with oral intake (odds ratio 2.0, 1.0 to 4.1) and with exercise (odds ratio 2.9, 1.9 to 4.5). Feeding tube duration was associated with oral intake with a coefficient of minus 123.4 days (minus 148.5 to minus 98.4), and exercise did not shorten tube duration. Swallowing-related quality of life was better with maintained oral intake. Both are observational associations: a patient able to keep eating through chemoradiotherapy is different from one who is not, and no amount of adjustment removes that entirely.
The randomised exercise trial. Carnaby-Mann and colleagues randomised 58 patients having chemoradiotherapy to usual care, a sham swallowing intervention or active daily swallowing exercises. The swallowing muscles, measured by magnetic resonance imaging, deteriorated less in the active arm, and functional swallowing, mouth opening, chemosensory acuity and salivation rate all deteriorated less. Fifty-eight patients across three arms is a small trial, and the imaging endpoint is the one it was powered for.
Adherence is the problem the field has not solved. The PRESTO trial randomised 148 patients with oropharyngeal cancer to the same four-week exercise programme delivered three ways: on paper with a diary, through an app, or face to face with a speech and language therapist. Adherence fell in all three groups over the four weeks (p below 0.001) and differed significantly between them (p below 0.001), with the therapist group highest throughout and the app group lowest. A separate randomised comparison in South India of 104 patients found clinician-directed adherence of 87.7 per cent against 61.6 per cent self-directed (p equals 0.004), with mobility exercises done more reliably than swallowing exercises.
Timing. A Spanish randomised trial of 52 patients compared starting the programme at diagnosis with starting after radiotherapy finished and found no significant differences between the groups except mouth opening at the end of radiotherapy, concluding that both early and late initiation are viable. That finding sits awkwardly beside the observational data, and it is a 52-patient trial.
What comes back, and when: swallowing is at its worst in the weeks immediately after radiotherapy ends and improves over the following three to six months. In the registry above, 66 per cent of patients were back on a solid diet by three to six months. Late radiation fibrosis can worsen swallowing again years later, and that late deterioration responds less well to therapy than the acute phase.
Striated muscle that is not loaded atrophies, and irradiated muscle that is not loaded atrophies while it fibroses. Swallowing exercises load the tongue base, the pharyngeal constrictors and the suprahyoid muscles through range and against resistance during the period when the fibrotic process is active, which is why the intervention is delivered during treatment rather than after it.
Query for this technology: (TITLE:"Swallowing therapy around head and neck radiotherapy" OR ABSTRACT:"Swallowing therapy around head and neck radiotherapy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Swallowing therapy around head and neck radiotherapy, not a curated reading list.
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Shares Head and neck reconstruction: the free flap, and what it gives back, Dry mouth, teeth and taste after head and neck radiotherapy, Cancer rehabilitation: the discipline that puts function back, Quality of life and the tags rejuvenation, survivorship, rehabilitation.
Shares Voice after the larynx is removed, Cancer rehabilitation: the discipline that puts function back, Quality of life, Late effects and survivorship toxicity and the tags rejuvenation, survivorship, rehabilitation.
Shares Scars, stiffness and contracture: shoulders, necks and jaws, Cancer rehabilitation: the discipline that puts function back, Quality of life, Late effects and survivorship toxicity and the tags rejuvenation, survivorship, rehabilitation.
Shares Cancer rehabilitation: the discipline that puts function back, Quality of life, Late effects and survivorship toxicity, Survivorship and late effects are neglected and the tags rejuvenation, survivorship, rehabilitation.
Shares Cancer rehabilitation: the discipline that puts function back, Quality of life, Late effects and survivorship toxicity, Survivorship and late effects are neglected and the tags rejuvenation, survivorship, rehabilitation.
Shares Scars, stiffness and contracture: shoulders, necks and jaws, Cancer rehabilitation: the discipline that puts function back, Quality of life, Survivorship and late effects are neglected and the tags rejuvenation, survivorship, rehabilitation.