termsTerm

Quality of life

aka QoL, HRQoL, health-related quality of life, patient-reported outcomes, patient-reported outcome, PROs, PRO, patient-reported, symptom burden, functional status, performance status, ECOG, ECOG 0-1, ECOG performance status, Karnofsky, time to deterioration, wellbeing

How a patient actually feels and functions day to day: symptoms, energy, mood, ability to work and live normally. Measured with questionnaires, it is the outcome that matters most alongside survival, and the one trials have historically neglected.

Standard instruments (EORTC QLQ-C30, FACT-G, EQ-5D) ask patients to rate pain, fatigue, nausea, physical and social function, and are collected repeatedly during a trial; results are reported as change from baseline or time until quality of life deteriorates. They matter because a drug that extends progression-free survival by two months while making patients feel worse may not be a good trade, and because regulators and health systems increasingly weigh them in approval and pricing. Performance status (ECOG 0 to 4) is the clinician's brief summary of how well a patient functions and gates who is fit enough for treatment and for trials.

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