Blinded independent central review (BICR)

Having outside radiologists who do not know the treatment assignment re-read every scan in a trial.

Regulators expect BICR for PFS and ORR endpoints in open-label trials to remove investigator bias; discordance between local and central reads is common and affects event counts. Delivered by imaging core labs.

Trials: what this kind of term is about · animated schematic, not to scale