termsTerm
DM4
aka ravtansine, soravtansine payload, ravtansine, soravtansine
DM4 is a maytansinoid payload released in a form that can cross membranes, giving mirvetuximab soravtansine a bystander effect that DM1 lacks.
DM4 (ravtansine or soravtansine) is attached through a hindered disulfide linker (sulfo-SPDB). After cleavage the payload is S-methylated inside the cell into a neutral, permeable form, so it can diffuse into neighbouring cells. Ocular toxicity (keratopathy, blurred vision) is the dose-limiting effect and is managed with steroid eye drops.
Category
ADC chemistry