termsTerm
MMAE
aka monomethyl auristatin E, vedotin payload, monomethyl auristatin E, vedotin
MMAE is the most widely used tubulin-blocking ADC payload: it stops cells dividing and leaks into neighbouring cells. Nerve damage is its signature side effect.
Monomethyl auristatin E is a synthetic analogue of dolastatin 10 that binds tubulin and halts mitosis. Released by cleavable linkers (typically valine-citrulline), it is membrane permeable, giving a strong bystander effect. It is a substrate for P-glycoprotein, which drives resistance. Peripheral neuropathy and neutropenia are class effects seen with brentuximab vedotin, enfortumab vedotin, polatuzumab vedotin and tisotumab vedotin.
Category
ADC chemistry