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Gastric adenocarcinoma and proximal polyposis of the stomach is a rare inherited condition, caused by a change in the control region of the APC gene, that fills the upper stomach with polyps and raises the risk of stomach cancer rather than bowel cancer. Stomach checks start at 15, and removing the stomach is considered by 30 to 35.
Caused by pathogenic variants in the APC promoter 1B, with fundic gland polyposis of the proximal stomach and a propensity to gastric rather than colorectal cancer. The AACR 2024 paediatric update, which added it after the 2017 recommendations, advises upper endoscopy from 15, consideration of prophylactic gastrectomy by 30 to 35 according to fundic gland polyps, dysplasia and family history, and a single baseline colonoscopy at 15 or at diagnosis if later, as it does not carry a high colorectal cancer risk.
In plain words · APC (Adenomatous polyposis coli protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Hepatocellular carcinoma and 5 more.
Showing the target this term concerns: APC.
Shares Gastrectomy, Invitae Common Hereditary Cancers Panel, Endoscopy (EGD, EUS, ERCP), Hereditary cancer syndromes and the tag hereditary.
Shares Invitae Common Hereditary Cancers Panel, Endoscopy (EGD, EUS, ERCP), Hereditary cancer syndromes, Germline (hereditary) testing and the tag hereditary.
Shares Invitae Common Hereditary Cancers Panel, Endoscopy (EGD, EUS, ERCP), Hereditary cancer syndromes, Germline (hereditary) testing and the tag hereditary.
Shares Invitae Common Hereditary Cancers Panel, Endoscopy (EGD, EUS, ERCP), Hereditary cancer syndromes, Germline (hereditary) testing and the tag hereditary.
Shares Hereditary cancer syndromes, Germline (hereditary) testing and the tag hereditary.
Shares Hereditary cancer syndromes, Germline (hereditary) testing and the tag hereditary.
Shares Hereditary cancer syndromes, Germline (hereditary) testing and the tag hereditary.
Shares Hereditary cancer syndromes, Germline (hereditary) testing and the tag hereditary.
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