Gray unit (Gy)
The unit of radiation dose absorbed by tissue: one gray is one joule per kilogram. A curative course is typically 50-70 Gy in total; a single bone-pain treatment is 8 Gy. Radiopharmaceuticals are prescribed by activity in becquerels (GBq) instead.
Because biological effect depends on both total dose and dose per fraction, different schedules are compared with the equivalent dose in 2 Gy fractions (EQD2) or biologically effective dose (BED); cervical brachytherapy aims for ≥85 Gy EQD2, early lung SBRT for BED ≥100 Gy. Dose escalation beyond 60 Gy did not help in stage III lung cancer (RTOG 0617) but did in prostate cancer. For radioligand therapy the administered activity (7.4 GBq of 177Lu-PSMA-617) is fixed, and dosimetry estimates the resulting gray to tumour and kidneys. Whole-body doses above about 4 Gy are lethal without marrow rescue, which is the basis of total body irradiation conditioning.
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not linked directly; found by shared links- TermBone metastases and skeletal-related events
Shares Stereotactic body radiotherapy (SBRT / SABR), Hypofractionation (fewer, larger radiotherapy doses).
- IdeaAlpha-emitting PSMA therapy at first metastatic diagnosis
- TechnologyAuger-electron therapy
- InstitutionSahlgrenska University Hospital / Sahlgrenska Center for Cancer Research
- TermHalf-life
- TechnologyAlpha-emitter nanogenerators and daughter trapping
- TermPRRT (peptide receptor radionuclide therapy)
- InstitutionInternational Atomic Energy Agency – Rays of Hope