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A single high dose of radiation delivered to a brain tumour or metastasis by beams converging from all sides, so the target gets a destructive dose while the surrounding brain gets little; no scalpel is involved despite the name. It treats metastases up to about 3-4 cm and has replaced whole-brain radiotherapy for limited disease because it spares cognition.
Gamma Knife, CyberKnife and linac-based SRS treat brain metastases up to about 3-4 cm (or several at once) with local control above 80% and have replaced whole-brain radiotherapy for limited disease because they spare cognition (N0574, JLGK0901). Larger cavities after surgery get fractionated stereotactic radiotherapy in 3-5 sessions. Modern practice combines SRS with CNS-active drugs (osimertinib, tucatinib, T-DXd), and trials now test whether upfront SRS can be deferred when such drugs are available.
Showing the technology this term belongs to: SBRT / SABR (stereotactic radiotherapy).
With image guidance, a larger safety margin around a brain metastasis did not buy better tumour control and added healthy brain to the high-dose region. It is one of the few randomised tests of a margin itself.
Treating the brain before the cancer gets there works in small-cell lung cancer, and it is the proof of principle behind every later attempt to prevent rather than treat brain metastases.
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Shares Triple-negative breast cancer (TNBC) and the tag precision.
Shares Triple-negative breast cancer (TNBC) and the tag precision.
Shares Triple-negative breast cancer (TNBC) and the tag precision.
Shares Triple-negative breast cancer (TNBC) and the tag precision.
Shares Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission, Lung cancer (all types), Triple-negative breast cancer (TNBC) and the tag precision.
Shares Triple-negative breast cancer (TNBC) and the tag precision.