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Ways of checking, before the operation ends, whether cancer reaches the edge of the breast tissue removed, so the surgeon can take more there and then instead of operating again days later. In randomised trials a radiofrequency probe cut second operations from 25.8 to 19.8 per cent, and routinely shaving an extra layer from the cavity cut them from 21 to 10 per cent.
After breast-conserving surgery the margin is normally read by the pathologist days later, and one woman in five in England had a second operation within three months (55,297 women, 2005 to 2008). Intraoperative methods try to give that answer while the cavity is still open.
A 2017 meta-analysis of 35 studies pooled their accuracy against final histology. Frozen section had sensitivity 86 per cent and specificity 96 per cent, imprint cytology 91 and 95, intraoperative ultrasound 59 and 81, specimen radiography 53 and 84, and optical spectroscopy 85 and 87. The authors concluded that frozen section and cytology are the most accurate, and that they are resource intensive and slow to report, which is why they have not spread. A 2021 meta-analysis of 19 frozen-section studies and 6,769 cases reported an average reoperation rate of 5.9 per cent where frozen section was used.
Two randomised trials measured what checking more changes. In 596 patients with non-palpable cancers, adding the MarginProbe radiofrequency spectroscopy device to standard imaging, with no intraoperative pathology, lowered re-excision from 25.8 to 19.8 per cent; its false-positive rate was 53.6 per cent, so extra tissue was often taken from clear margins, although the total volume removed did not differ significantly. In 235 women, shaving a further layer of tissue from every cavity wall after the lumpectomy halved positive margins (19 against 34 per cent) and second operations (10 against 21 per cent), with no difference in complications. Neither trial measured local recurrence or survival.
The fluorescent dye pegulicianine has its own record. What these methods buy is fewer second operations, which is a real gain for the patient; a margin wider than clear does not lower recurrence, so more precision beyond a clear edge has not been shown to buy local control.
Each method answers the pathologist's question earlier with a different signal. Frozen section freezes and cuts a thin slice of the margin for a microscope in about the time of the operation; imprint cytology touches the specimen surface to a slide and looks for cancer cells; specimen radiography X-rays the removed tissue to see whether the mass or its calcifications reach the edge; intraoperative ultrasound images the lesion and specimen; radiofrequency spectroscopy reads the electrical properties of the specimen surface, which differ between cancer and normal breast; and cavity shaving needs no signal at all, taking an extra rim from every wall.
Query for this technology: (TITLE:"Intraoperative margin assessment in breast-conserving surgery" OR ABSTRACT:"Intraoperative margin assessment in breast-conserving surgery" OR TITLE:"intraoperative margin assessment" OR ABSTRACT:"intraoperative margin assessment" OR TITLE:"frozen section of lumpectomy margins" OR ABSTRACT:"frozen section of lumpectomy margins" OR TITLE:"specimen radiography" OR ABSTRACT:"specimen radiography") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Intraoperative margin assessment in breast-conserving surgery, not a curated reading list.
Shares Margins after breast-conserving surgery, and second operations, Real-time margin assessment and image-guided surgery as the global standard, Pegulicianine, Intraoperative fluorescence and Cerenkov imaging systems (SPY, Firefly, LumiSystem, LightPath) and the tag precision.
Shares HER2-positive breast cancer, Breast cancer (all types), Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer and the tag precision.
Shares Fluorescence-guided surgery, Breast cancer (all types), Triple-negative breast cancer (TNBC) and the tag precision.
Shares Intraoperative fluorescence and Cerenkov imaging systems (SPY, Firefly, LumiSystem, LightPath), Ductal carcinoma in situ (DCIS), Breast cancer (all types), Triple-negative breast cancer (TNBC) and the tag precision.
Shares HER2-positive breast cancer and the tag precision.
Shares Breast cancer (all types), Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer and the tag precision.
Shares Breast cancer (all types) and the tag precision.
Shares Breast cancer (all types) and the tag precision.
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