Fluorescence-guided surgery
Injecting a dye that makes tumour glow so the surgeon can see exactly where to cut.
5-ALA in glioma increases complete resection rates; pafolacianine (Cytalux) finds occult ovarian and lung lesions; pegulicianine (Lumisight, 2024) detects residual breast cancer in the lumpectomy cavity. Targeted probes (EGFR, PSMA, CEA) are in phase 2-3.
How it works
A tumour-selective fluorophore accumulates in the tumour and is imaged with near-infrared camera systems.
- Fewer positive margins and re-operations
- Millimetre depth penetration
A drink taken before brain surgery that makes high-grade glioma glow under blue light, letting surgeons remove more tumour safely.
An injected dye that makes ovarian and lung cancer deposits glow during surgery so surgeons can find lesions they would otherwise miss.
A cavity-imaging dye used during breast lumpectomy to spot leftover tumour before the operation ends, reducing second surgeries.
Latest papers
topQuery for this technology: (TITLE:"fluorescence-guided surgery" OR ABSTRACT:"fluorescence-guided surgery" OR TITLE:"fluorescence guided surgery" OR ABSTRACT:"fluorescence guided surgery" OR TITLE:"near-infrared fluorescence" OR ABSTRACT:"near-infrared fluorescence") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Fluorescence-guided surgery, not a curated reading list.
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