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Injecting a dye that makes tumour glow so the surgeon can see exactly where to cut.
In fluorescence-guided surgery a tumour-selective fluorophore accumulates in the tumour and is imaged with near-infrared camera systems, so the surgeon can see disease that is invisible under white light. 5-ALA in glioma increases complete resection rates; pafolacianine (Cytalux) finds occult ovarian and lung lesions; pegulicianine (Lumisight, 2024) detects residual breast cancer in the lumpectomy cavity. The clinical payoff is fewer positive margins and re-operations. Targeted probes against EGFR, PSMA, and CEA are in phase 2-3 and would extend the approach to more tumour types. The limitation is millimetre depth penetration, so the dye shows surface disease and cannot see deep into tissue. The simple version is that a dye makes the tumour glow so the surgeon knows exactly where to cut.
A tumour-selective fluorophore accumulates in the tumour and is imaged with near-infrared camera systems.
A drink taken before brain surgery that makes high-grade glioma glow under blue light, letting surgeons remove more tumour safely.
An injected dye that makes ovarian and lung cancer deposits glow during surgery so surgeons can find lesions they would otherwise miss.
A cavity-imaging dye used during breast lumpectomy to spot leftover tumour before the operation ends; in its main trial it spared a second operation for 9 of 62 patients whose margins were positive.
Query for this technology: (TITLE:"fluorescence-guided surgery" OR ABSTRACT:"fluorescence-guided surgery" OR TITLE:"fluorescence guided surgery" OR ABSTRACT:"fluorescence guided surgery" OR TITLE:"near-infrared fluorescence" OR ABSTRACT:"near-infrared fluorescence") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Fluorescence-guided surgery, not a curated reading list.
Shares Targeted axillary dissection (MD Anderson prospective study), European Society of Surgical Oncology, Society of Surgical Oncology, Surgical robots: da Vinci, Hugo, Versius and single-port systems and the tag precision.
Shares An independent evaluation unit for surgical robots and AI, paid on evidence, Chang Gung Memorial Hospital, European Society of Surgical Oncology, Society of Surgical Oncology and the tag precision.
Shares Targeted axillary dissection (MD Anderson prospective study), Sentinel node biopsy and the tag precision.
Shares Intraoperative margin assessment in breast-conserving surgery, Precision roadmap: margins measured in millimetres → tests that find a target → doses fitted to the person → precision that changes outcomes and the tag precision.
Shares A translation fund for academic surgical devices and radiotherapy technology, Precision roadmap: margins measured in millimetres → tests that find a target → doses fitted to the person → precision that changes outcomes, Surgery and radiotherapy cure most, get least and the tag precision.
Shares Intraoperative margin assessment in breast-conserving surgery, Precision roadmap: margins measured in millimetres → tests that find a target → doses fitted to the person → precision that changes outcomes and the tag precision.
Shares Precision roadmap: margins measured in millimetres → tests that find a target → doses fitted to the person → precision that changes outcomes and the tag precision.
Shares Chang Gung Memorial Hospital, Precision roadmap: margins measured in millimetres → tests that find a target → doses fitted to the person → precision that changes outcomes, Surgery and radiotherapy cure most, get least, Glioma & glioblastoma and the tag precision.