Loading
CPI-008 (cRGD-ZW800-1) is an experimental dye that sticks to tumour tissue so surgeons can see it under near-infrared light. It has been tested in phase 2 trials and has European orphan status for head and neck cancer.
CPI-008 is the code for cRGD-ZW800-1, a cyclic RGD peptide joined to the near-infrared dye ZW800-1. ClinicalTrials.gov lists investigator-led phase 2 trials in oral cancer (NCT04191460, completed) and laryngeal and hypopharyngeal cancer (NCT05752149, recruiting) at Erasmus Medical Center, and in pancreatic and bile duct tumours at Leiden University Medical Center (NCT05518071, completed). On 22 June 2026 the EMA granted orphan designation EU/3/26/3253 for the treatment of head and neck cancer to Curadel Surgical Innovations B.V.
A cyclic RGD peptide, which binds integrins on tumour cells and new blood vessels, joined to the zwitterionic near-infrared dye nizaracianine (ZW800-1), so that tumour tissue fluoresces under a near-infrared camera during surgery.
Treatment of head and neck cancer
EMA orphan designation EU/3/26/3253 for head and neck cancer, sponsor Curadel Surgical Innovations B.V. source
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"CPI-008" OR ABSTRACT:"CPI-008" OR TITLE:"cRGD-ZW800-1" OR ABSTRACT:"cRGD-ZW800-1" OR TITLE:"cyclo arginyl-glycyl-aspartyl-D-tyrosyl-lysyl -nizaracianine-1" OR ABSTRACT:"cyclo arginyl-glycyl-aspartyl-D-tyrosyl-lysyl -nizaracianine-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CPI-008, not a curated reading list.
Shares Fluorescence-guided surgery and the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/