Loading
PACAB-002 is an experimental nanoparticle form of the chemotherapy cabazitaxel from NaDeNo Nanoscience, given into the abdomen after ovarian cancer surgery to clear small deposits left behind. Its first trial in people has been approved, and it has orphan status in the European Union for ovarian cancer.
PACAB-002 is NaDeNo Nanoscience's lead candidate: cabazitaxel encapsulated without chemical modification in a biodegradable polymer matrix, designed for intraperitoneal treatment of peritoneal micrometastases in ovarian cancer. The company reports that in a preclinical ovarian cancer model a single intraperitoneal dose doubled median survival compared with free drug at the same dose. On 28 July 2026 the EMA granted orphan designation EU/3/26/3258 to cabazitaxel for the treatment of ovarian cancer, sponsored by Nadeno Nanoscience AS, and the company identifies PACAB-002 as the designated product. The clinical trial application for a phase 1 first-in-human trial, led at Erasmus MC in Rotterdam, was approved in October 2026.
Cabazitaxel, a second-generation taxane that stops cancer cells dividing by stabilising microtubules, encapsulated in biodegradable polymer nanoparticles whose surface chemistry favours tumour accumulation and retention in the peritoneal cavity, as the developer describes it.
1.PACAB-002 slips into a pocket on its target.
Treatment of ovarian cancer
EMA orphan designation EU/3/26/3258 of cabazitaxel for ovarian cancer, sponsor Nadeno Nanoscience AS (the company's product PACAB-002) source
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"PACAB-002" OR ABSTRACT:"PACAB-002") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PACAB-002, not a curated reading list.
Shares Ovarian cancer and the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/