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177Lu-FAP-VG11 is an experimental radioactive medicine from VitsGen Therapeutics that targets FAP, a protein on the support cells around many tumours. It is in an early hospital-led trial in China, and the FDA has given it orphan drug status for soft tissue sarcoma.
177Lu-FAP-VG11 is VitsGen Therapeutics' FAP-targeted radionuclide drug conjugate. The company reports higher FAP binding, tumour uptake, retention and tumour-to-kidney ratio than comparators in preclinical studies. China's NMPA accepted its IND application (acceptance number CXHL2600985) on 12 August 2026, and an early phase 1 investigator-initiated trial in FAP-positive advanced solid tumours, sponsored by Shandong Cancer Hospital and Institute, is registered as NCT07808177. On 22 October 2026 the FDA granted orphan drug designation for the treatment of soft tissue sarcoma.
A ligand that binds fibroblast activation protein (FAP), carried by fibroblasts in the tumour microenvironment, chelated to lutetium-177, whose beta particles damage DNA in the targeted cells and in neighbouring tumour cells (the crossfire effect), as the developer describes it. Connects to FAP.
1.177Lu-FAP-VG11 binds FAP on the cancer cell or is taken up by it.
treatment of soft tissue sarcoma
FDA orphan drug designation for soft tissue sarcoma, granted to VitsGen Therapeutics source
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Query for this drug: (TITLE:"177Lu-FAP-VG11" OR ABSTRACT:"177Lu-FAP-VG11" OR TITLE:"FAP-VG11" OR ABSTRACT:"FAP-VG11" OR TITLE:"177Lu-FAP-VG11 Injection" OR ABSTRACT:"177Lu-FAP-VG11 Injection") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about 177Lu-FAP-VG11, not a curated reading list.
Shares Sarcomas (soft tissue, bone, GIST) and the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
Shares the tags pipeline, orphan-designation.
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