OnCo
drugsProductApproved2010🇪🇺🇬🇧🇯🇵🇨🇳🇦🇺

Cabazitaxel

A second taxane that works after docetaxel and beat a second hormone pill head-to-head (CARD).

TROPIC (2010) post-docetaxel OS benefit; CARD (2019) superior to abiraterone/enzalutamide switch after prior ARPI and docetaxel; comparator in TheraP (lost to 177Lu-PSMA-617 on PSA50) and XALute.

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Cabazitaxel · 2D coordinates (no PubChem conformer)
PubChem
Modality
Cytotoxic chemotherapy (taxane)
Mechanism
Taxane with low P-glycoprotein affinity, active in docetaxel-resistant disease.
Brand / code
Jevtana
Medicare
Part B (clinician-administered)

Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. Generics entered the US market in 2021–2024 after patent litigation.

Commercial insurance
covered with prior authorisation

Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments. Plans typically require prior docetaxel.

Assistance programmes

20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.

Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.

NICE recommendedNICE TA391 · 2016SMC: accepted
Appraised for
Metastatic hormone-relapsed prostate cancer after docetaxel
NHS England
Routinely funded for the appraised indication (or via managed access)

Sources: NICE TA391 · SMC advice: cabazitaxel. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

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Approvals

RegionYearIndication
US2010mCRPC after docetaxel

Trials

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ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
105 studies14 recruiting84 Phase 220 Phase 3
Search “Cabazitaxel” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Cabazitaxel
intervention: Cabazitaxel
Open on ClinicalTrials.gov →

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Landmark trials in OnCo

Latest papers

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Literature trend89 papers in the last 12 months+39% vs prior 12How this is computed
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Cabazitaxel" OR ABSTRACT:"Cabazitaxel" OR TITLE:"Jevtana" OR ABSTRACT:"Jevtana") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cabazitaxel, not a curated reading list.

Connected

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