Real-time margin assessment and image-guided surgery as the global standard
Surgeons often cannot see where a tumour ends. Fluorescent dyes and AI-read imaging in the operating theatre can show them, cutting repeat operations. Make this routine everywhere.
Positive margins lead to re-operation or recurrence in breast, head and neck, prostate and gastrointestinal surgery. Tumour-targeted fluorescent agents (pegulicianine approved for breast lumpectomy, PSMA- and folate-targeted agents), intraoperative mass spectrometry and rapid AI histology can assess margins during surgery. The proposal is a programme to standardise and validate these tools across common operations, integrate them into low-cost surgical imaging platforms suitable for district hospitals, and make margin status with intraoperative assessment a quality indicator.
- Surgery and radiotherapy cure most, get least · Surgery and radiotherapy cure more people than drugs do, but attract a fraction of the research investment.
- Most of the world has almost no cancer care · Seven in ten cancer deaths happen in low- and middle-income countries, where radiotherapy, pathology, surgery and drugs are scarce.
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not linked directly; found by shared links- IdeaA pragmatic trial network for intraoperative margin tools, paid on margin reduction
Shares Optical & fluorescence imaging, Fluorescence-guided surgery, Surgery and radiotherapy cure most, get least, Head and neck squamous cell carcinoma.
- ProductPegulicianine
Shares Optical & fluorescence imaging, Fluorescence-guided surgery, HR-positive / HER2-negative breast cancer.
- Product5-Aminolevulinic acid (oral, for glioma surgery)
Shares Optical & fluorescence imaging, Fluorescence-guided surgery.
- InstitutionChao Family Comprehensive Cancer Center, UC Irvine
Shares Optical & fluorescence imaging, Fluorescence-guided surgery, Head and neck squamous cell carcinoma.
- IdeaMake one-week radiotherapy the default in overloaded systems
Shares Surgery and radiotherapy cure most, get least, Most of the world has almost no cancer care, Prostate cancer, HR-positive / HER2-negative breast cancer.
- ProductPafolacianine
Shares Optical & fluorescence imaging, Fluorescence-guided surgery.
- IdeaStructured mentorship so district general surgeons perform common cancer operations safely
Shares Surgery and radiotherapy cure most, get least, Most of the world has almost no cancer care, HR-positive / HER2-negative breast cancer.
- IdeaMobile diagnostic units that biopsy, scan and treat on the same visit
Shares Digital pathology & AI, Most of the world has almost no cancer care, HR-positive / HER2-negative breast cancer.