Taxanes (paclitaxel, docetaxel, nab-paclitaxel)
Chemotherapy drugs originally from the yew tree that freeze the cell's internal scaffolding (microtubules) so it cannot divide. Used in breast, lung, ovarian, prostate, gastric and head and neck cancers; their main lasting side effect is nerve damage in the hands and feet.
Paclitaxel (Taxol, 1992) and docetaxel are given with platinum in ovarian and lung cancer, sequentially with anthracyclines in breast cancer, as the chemotherapy partner in KEYNOTE-522 and CLEOPATRA, and as first chemotherapy in prostate cancer (docetaxel, then cabazitaxel after progression). Nab-paclitaxel is an albumin-bound form that avoids solvent hypersensitivity and is standard with gemcitabine in pancreatic cancer. Peripheral neuropathy, alopecia, neutropenia and hypersensitivity reactions are the main toxicities; taxane-derived payloads are less common in ADCs than tubulin inhibitors such as MMAE, which act on the same target.
Pages like this
not linked directly; found by shared links- IdeaDose chemotherapy by muscle mass, not body surface area
Shares Docetaxel, Paclitaxel / nab-paclitaxel, Cytotoxic chemotherapy.
- IdeaA non-profit manufacturer for generic cancer drugs in chronic shortage
- IdeaA prevention programme for chemotherapy nerve damage: SARM1 inhibitors, cooling and compression
- IdeaChoose regimens by infusion-chair hours, not just efficacy, where chairs are the constraint
- ProductGemcitabine + nab-paclitaxel
- ProductOxaliplatin
Shares Peripheral neuropathy (chemotherapy-induced), Cytotoxic chemotherapy.
- IdeaPublic-option manufacturing for essential generic cancer drugs in shortage
- TrialINTERLACE