Tumour hypoxia
Regions of a tumour that have outgrown their blood supply and are short of oxygen. They resist radiotherapy and some chemotherapy, and drive the tumour to become more aggressive.
Overview
Fast-growing tumours have chaotic, leaky blood vessels, leaving pockets of cells living on very little oxygen. Hypoxic cells need up to three times the radiation dose to be killed, switch on HIF-driven survival programmes, become more invasive and are selected for genomic instability. Hypoxia can be imaged with PET tracers, measured by gene signatures and targeted with sensitisers, hypoxia-activated drugs, hyperthermia and dose escalation.
Showing the technology this term belongs to: Tumour hypoxia: imaging and modification.
Similar pages
not linked directly; found by shared links- TermOxygen enhancement ratio
Shares Tumour hypoxia: imaging and modification and the tag radiation-wave1.
- TechnologyAdaptive radiotherapy (online replanning)
Shares Dose painting and biologically guided radiotherapy and the tag radiation-wave1.
- TreatmentNimorazole
Shares DAHANCA 5, Tumour hypoxia: imaging and modification, Radiosensitisers.
- TechnologyPET (positron emission tomography)
Shares Dose painting and biologically guided radiotherapy, Tumour hypoxia: imaging and modification.