trialsTrialRecruiting

AHOD2131 (COG / NCTN)

Asks whether early-stage Hodgkin lymphoma in children and adults can be treated with immunotherapy instead of some chemotherapy and radiation.

Response-adapted design using PET after two cycles; primary endpoint PFS; also measures late effects. It is ongoing, with no results yet (September 2026).

Setting

Newly diagnosed stage I-II classical Hodgkin lymphoma, age 5-60: standard therapy vs brentuximab vedotin + nivolumab (response-adapted), with or without radiation

Phase

Phase 3

Sponsor

Children's Oncology Group / NCI

Registry

NCT05675410

Key papers

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rctNew England Journal of Medicine 2024changed practice

SWOG S1826: nivolumab plus AVD chemotherapy versus brentuximab-AVD for advanced Hodgkin lymphoma in adolescents and adults

S1826 moved checkpoint blockade into first-line Hodgkin lymphoma and made N-AVD a preferred regimen for advanced disease in patients from adolescence to older age, while removing radiotherapy for most. It also showed the value of a single trial spanning paediatric and adult groups. Longer follow-up is needed for overall survival and late immune effects in young patients.

Connected

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Pages like this

not linked directly; found by shared links

Evidence strength35/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

ProvenanceLast edited 2026-09-09 · Jude Gomila · Editing pass: every TL;DR and summary stands alone · diff · file · history

Sources & links

ClinicalTrials.gov NCT05675410

Data

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