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This early study tests LOXO-783 alone and with other cancer treatments in tumors with selected PIK3CA gene changes. It looks at safety, dose and early treatment activity.
This early study tests LOXO-783 alone and with other cancer treatments in tumors with selected PIK3CA gene changes. It looks at safety, dose and early treatment activity.
Interventional study registered as NCT05307705, sponsored by Eli Lilly and Company. Registry phase: 1. Registry enrollment is 260 participants (estimated). Registry status checked October 10, 2026: recruiting. UCSF lists this study as open to eligible people; local availability and overall registry status are separate. See the registry for full eligibility and current sites.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-10. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Imlunestrant, Abemaciclib, UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Paclitaxel / nab-paclitaxel, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares Abemaciclib, UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Paclitaxel / nab-paclitaxel, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Paclitaxel / nab-paclitaxel, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Paclitaxel / nab-paclitaxel, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Paclitaxel / nab-paclitaxel, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
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