Safety and Efficacy of SPH4336 in Combination With Endocrine Therapy in the Treatment of Locally Advanced or Metastatic Breast Cancer
A phase 2/3 trial testing SPH4336 in HR-positive / HER2-negative breast cancer, now recruiting.
Overview
Safety and Efficacy of SPH4336 in Combination With Endocrine Therapy in the Treatment of Locally Advanced or Metastatic Breast Cancer is a phase 2/3 interventional study registered as NCT05860465, led by Shanghai Pharmaceuticals, and recruiting when checked on 2026-09-11. Official title: A Phase II/III Study of SPH4336 in Combination With Endocrine Therapy in the Treatment of HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer That Progressed on CDK4/6 Inhibitor Combined With Endocrine Therapy. Planned enrolment is 254 participants (estimated). The study started in 2023-09-08 and primary completion is expected in 2026-12-01. No results have been posted on ClinicalTrials.gov.
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