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A phase 2 trial of serplulimab and bevacizumab in colorectal cancer, run by The First Affiliated Hospital with Nanjing Medical University, not yet recruiting.
Neoadjuvant Therapy for Locally Advanced Low Rectal Cancer (SMARTi-RC01) is a phase 2, randomised interventional study registered as NCT07134101 by The First Affiliated Hospital with Nanjing Medical University, with a registry enrolment figure of 138 participants, started 2025-09-01 and due to reach its primary completion in 2028-08-31. Interventions recorded: Serplulimab; Bevacizumab; Short-Course Radioterapy; Chemotherapy (CAPOX or capecitabine). Conditions listed: Colorectal Cancer (Diagnosis). Primary outcome: Complete Remission (CR) Rate assessed by pathology, MRI, endoscopy, and clinical examination. Colorectal eligibility wording from the registry: "Diagnosis: Pathologically confirmed rectal adenocarcinoma with proficient mismatch repair (pMMR) / microsatellite stable (MSS) status, based on biopsy of the primary tumor". No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Serplulimab, Mismatch-repair deficient (MSI-high) colorectal cancer, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Serplulimab, Mismatch-repair deficient (MSI-high) colorectal cancer, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Serplulimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.
Shares Serplulimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.
Shares Serplulimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.
Shares Serplulimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer, Immune checkpoint inhibitors and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Colorectal cancer trials open today (registry snapshot), Rectal cancer, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Colorectal cancer trials open today (registry snapshot), Rectal cancer, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.
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