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A phase 3 trial of FOLFOXIRI, cAPOX (capecitabine, oxaliplatin) and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by J. W. A. Burger, not yet recruiting.
Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT07472868 by J. W. A. Burger, with a registry enrolment figure of 394 participants, started 2026-03-03 and due to reach its primary completion in 2030-03-02. Interventions recorded: FOLFOXIRI; CAPOX; FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin); Chemoradiotherapy; Total mesorectal excision (+/- IORT); Watch-and-wait approach. Conditions listed: Locally Advanced Rectal Carcinoma. Primary outcome: Complete response. Colorectal eligibility wording from the registry: "* Histopathological confirmed rectal cancer". Sites: Netherlands. No results are recorded here; the registry entry is the source.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), CAPOX (capecitabine, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), CAPOX (capecitabine, oxaliplatin), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), CAPOX (capecitabine, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), CAPOX (capecitabine, oxaliplatin), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.