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A phase 2 trial of nivolumab in colorectal cancer, run by Fred Hutchinson Cancer Center, not yet recruiting.
Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial is a phase 2, interventional study registered as NCT07576725 by Fred Hutchinson Cancer Center, with a registry enrolment figure of 50 participants, started 2026-12-01 and due to reach its primary completion in 2029-08-31. Interventions recorded: Biospecimen Collection; Computed Tomography; Magnetic Resonance Imaging; Nivolumab. Conditions listed: Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8; Hodgkin Lymphoma; Kaposi Sarcoma; Metastatic Acral Lentiginous Melanoma; Metastatic Basal Cell Carcinoma; Metastatic Cervical Carcinoma; Metastatic Clear Cell Renal Cell Carcinoma; Metastatic Colorectal Carcinoma; Metastatic Cutaneous Melanoma; Metastatic Head and Neck Squamous Cell Carcinoma; Metastatic Kaposi Sarcoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Merkel Cell Carcinoma; Metastatic Mucosal Melanoma; Metastatic Skin Squamous Cell Carcinoma; Metastatic Urothelial Carcinoma; Stage III Cervical Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8; Stage III Lung Cancer AJCC v8; Stage III Renal Cell Cancer AJCC v8; Stage IV Cervical Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Unresectable Acral Lentiginous Melanoma; Unresectable Basal Cell Carcinoma; Unresectable Cervical Carcinoma; Unresectable Clear Cell Renal Cell Carcinoma; Unresectable Colorectal Carcinoma; Unresectable Cutaneous Melanoma; Unresectable Head and Neck Squamous Cell Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Malignant Solid Neoplasm; Unresectable Merkel Cell Carcinoma; Unresectable Mucosal Melanoma; Unresectable Skin Squamous Cell Carcinoma; Unresectable Urothelial Carcinoma. Primary outcome: Objective response. Colorectal eligibility wording from the registry: "* Colorectal cancer with high microsatellite instability (MSI) or mismatch repair deficiency". Sites: Uganda. No results are recorded here; the registry entry is the source.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Nivolumab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Nivolumab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Nivolumab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Nivolumab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Nivolumab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.