Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07580339 by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, with a registry enrolment figure of 30 participants, started 2026-10 and due to reach its primary completion in 2030-10. Interventions recorded: DCSZ11; Radiation; Capecitabine; Oxaliplatin. Conditions listed: Rectal Cancer. Primary outcome: Composite Complete Response (compCR) Rate; Number of participants experiencing a drug-related toxicity requiring treatment discontinuation. Colorectal eligibility wording from the registry: "* Rectal cancer (with tumor tissue present at or below the peritoneal reflection) as determined by MRI pelvis or endoscopic ultrasound". Sites: United States. No results are recorded here; the registry entry is the source.