FcRH5 expression
FcRH5 is a third myeloma surface target after BCMA and GPRC5D. Cevostamab, the FcRH5 x CD3 bispecific, is in phase 3; no approval or threshold exists yet.
Overview
FcRH5 is expressed on nearly all myeloma cells and gained on 1q21. Cevostamab is being tested in the phase 3 CAMMA 2 trial (NCT05535244) against standard combinations in relapsed or refractory myeloma after BCMA-directed therapy; trials enrol without an FcRH5 expression threshold. No regulator has approved an FcRH5-directed drug.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FcRH5 is a surface protein found almost only on B cells and myeloma plasma cells, which makes it a target for T-cell engaging antibodies in multiple myeloma.
FcRH5 is not something you will be tested for today; it is the target of cevostamab, an experimental bispecific antibody available in trials for myeloma that has come back after BCMA-directed treatment.
Written only from the label or guideline text cited on this page. Not medical advice; your own report and the reading your team gives it come first.
The label names the antigen in the drug's description but does not require it to be measured before treatment; no approval threshold exists for this readout.
“Cevostamab in relapsed or refractory multiple myeloma (CAMMA 2)”
ClinicalTrials.gov NCT05535244 (CAMMA 2)No approval uses this readout as a threshold. It is defined by CAMMA 2: cevostamab versus standard therapy in relapsed or refractory multiple myeloma (NCT05535244).
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