BCMA expression
BCMA is the plasma-cell antigen behind the myeloma bispecifics and CAR-T cells. None of their labels requires a BCMA test; expression is near-universal, and loss through BCMA gene deletion is a documented escape route.
Overview
Teclistamab, elranatamab and linvoseltamab (BCMA x CD3 bispecifics), idecabtagene vicleucel and ciltacabtagene autoleucel (BCMA CAR-T) and belantamab mafodotin (BCMA ADC) are labelled for relapsed or refractory multiple myeloma by prior lines of therapy, with BCMA named in the mechanism of action only. Biallelic TNFRSF17 loss and extracellular-domain mutations after BCMA-directed therapy are reported in the literature and motivate GPRC5D- and FcRH5-directed alternatives.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BCMA is a survival receptor on plasma cells, and the target that made CAR-T and bispecifics work in multiple myeloma.
No BCMA test is needed before a BCMA bispecific or CAR-T; the antigen is assumed. If myeloma returns after one BCMA-directed treatment, your team may test whether BCMA is still present before choosing another, or move to a drug aimed at GPRC5D.
Written only from the label or guideline text cited on this page. Not medical advice; your own report and the reading your team gives it come first.
The label names the antigen in the drug's description but does not require it to be measured before treatment; no approval threshold exists for this readout.
“TECVAYLI is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager”
TECVAYLI prescribing information (DailyMed)No approval uses this readout as a threshold.
Similar pages
not linked directly; found by shared links- BiomarkerB7-H3 (CD276) expression
Shares the tags biomarker, surface-antigen, no-threshold.
- BiomarkerCEACAM5 expression
Shares the tags biomarker, surface-antigen, no-threshold.
- BiomarkerDLL3 expression
Shares the tags biomarker, surface-antigen, no-threshold.
- BiomarkerHER3 expression
Shares the tags biomarker, surface-antigen, no-threshold.
- BiomarkerNectin-4 expression
Shares the tags biomarker, surface-antigen, no-threshold.
- BiomarkerTissue factor expression
Shares the tags biomarker, surface-antigen, no-threshold.
- BiomarkerTROP2 expression
Shares the tags biomarker, surface-antigen, no-threshold.
- BiomarkerCD22 expression (CD22-positive)
Shares Antigen escape (antigen loss, lineage switch) and the tags biomarker, surface-antigen.