Hairy cell leukaemia

What changed: Hairy cell leukaemia

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Every dated change on the records linked to Hairy cell leukaemia, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

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September 2026 · 1

2026-09-08This recordHairy cell leukaemia
Facts on this page last checked
When this page itself was last checked or edited.

2021 · 1

2021MilestoneVemurafenib
Vemurafenib + rituximab: chemo-free durable remissions (NEJM)
A milestone in how this cancer is treated.

2018 · 2

2015 · 1

2015MilestoneVemurafenib
Vemurafenib active in relapsed HCL
A milestone in how this cancer is treated.

2011 · 1

2011MilestoneBRAF
BRAF V600E found in all classic HCL (Tiacci, NEJM)
A milestone in how this cancer is treated.

2004 · 1

2004ApprovalCladribine
Cladribine approved in EU
Hairy cell leukaemia (Litak, subcutaneous)

1993 · 1

1993ApprovalCladribine
Cladribine approved in US
Active hairy cell leukaemia

1991 · 1

1991ApprovalPentostatin
Pentostatin approved in US
Hairy cell leukaemia (initially alpha-interferon-refractory; later untreated disease)

1990 · 1

1990MilestoneCladribine
Cladribine: durable remissions after one course (Piro, NEJM)
A milestone in how this cancer is treated.

1986 · 1

1986ApprovalInterferon alfa-2a/2b
Interferon alfa-2a/2b approved in US
Hairy cell leukaemia

1984 · 1

1984MilestoneInterferon alfa-2a/2b
Interferon alfa: first effective therapy
A milestone in how this cancer is treated.

1958 · 1

1958MilestoneHairy cell leukaemia
Bouroncle describes 'leukemic reticuloendotheliosis'
A milestone in how this cancer is treated.