Moxetumomab pasudotox
An immunotoxin for hairy cell leukaemia that produced lasting remissions in relapsed patients but was withdrawn from sale in 2023 for commercial reasons.
Pivotal study (Kreitman, Leukemia 2018): 41% complete remission (30% durable) in multiply relapsed HCL. Capillary leak and haemolytic uraemic syndrome were the key toxicities. AstraZeneca withdrew it from the US market in 2023 (low use); a compassionate supply continued via the NIH.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2018 | Relapsed/refractory hairy cell leukaemia after ≥2 systemic therapies including a purine analogue — Withdrawn from market 2023 |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Moxetumomab pasudotox" OR ABSTRACT:"Moxetumomab pasudotox" OR TITLE:"Lumoxiti" OR ABSTRACT:"Lumoxiti") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Moxetumomab pasudotox, not a curated reading list.