Elongation factor 2 (EEF2)
EEF2 is the ribosome's motor for moving along messenger RNA; the CML drug omacetaxine stalls protein production by acting at this step.
Overview
Eukaryotic elongation factor 2 (EEF2) drives the translocation step of protein synthesis, moving the ribosome one codon along the messenger RNA after each amino acid is added. Omacetaxine mepesuccinate (homoharringtonine) binds the ribosome's A-site and blocks the first elongation steps, so short-lived proteins such as BCR-ABL1 and MCL1 fall quickly; the drug is approved for chronic myeloid leukaemia after two tyrosine kinase inhibitors.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EEF2 is the ribosome's motor for moving along messenger RNA; the CML drug omacetaxine stalls protein production by acting at this step.
- 1 · What it is
EEF2 is the ribosome's motor for moving along messenger RNA; the CML drug omacetaxine stalls protein production by acting at this step.
- 2 · What goes wrong in cancer
A GTPase of the translation machinery; its activity is switched off by phosphorylation from eEF2 kinase under stress and starvation, one of the ways cells throttle protein synthesis.
- 3 · How drugs use it
No product in this corpus aims at Elongation factor 2 (EEF2) yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Biology
A GTPase of the translation machinery; its activity is switched off by phosphorylation from eEF2 kinase under stress and starvation, one of the ways cells throttle protein synthesis.
- All nucleated cells (housekeeping translation factor)
- Highly active in rapidly dividing leukaemia and lymphoma cells
Latest papers
topQuery for this target: (TITLE:"Elongation factor 2" OR ABSTRACT:"Elongation factor 2" OR TITLE:"EEF2" OR ABSTRACT:"EEF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Elongation factor 2 (EEF2), not a curated reading list.