Elongation factor 2 (EEF2)
EEF2 is the ribosome's motor for moving along messenger RNA; the CML drug omacetaxine stalls protein production by acting at this step. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
A GTPase of the translation machinery; its activity is switched off by phosphorylation from eEF2 kinase under stress and starvation, one of the ways cells throttle protein synthesis.
- All nucleated cells (housekeeping translation factor)
- Highly active in rapidly dividing leukaemia and lymphoma cells
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"Elongation factor 2" OR ABSTRACT:"Elongation factor 2" OR TITLE:"EEF2" OR ABSTRACT:"EEF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Elongation factor 2 (EEF2), not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/eef2.json. Licence CC BY-NC 4.0.