What changed: Mesothelioma
Every dated change on the records linked to Mesothelioma, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.
September 2026 · 1
2026 · 3
- 2026GuidelineMesotheliomaGuideline NCCN Mesothelioma: Pleural v1.2026: Diagnosis and staging
CT and PET/CT; thoracoscopic biopsy with IHC panel (calretinin, WT1, D2-40; BAP1 and MTAP loss support malignancy); histology and BAP1/MTAP status recorded for treatment planning. (NCCN MPM guideline)
- 2026Trial resultDREAM3RDREAM3R reported
Stopped early; primary endpoint not met.
- 2026MilestoneDREAM3RDREAM3R stopped early; PRMT5 inhibitors and mesothelin cell therapies advance
A milestone in how this cancer is treated.
2025 · 1
2024 · 4
- 2024Trial resultBEAT-meso (ETOP 13-18)BEAT-meso (ETOP 13-18) reported
OS not significantly improved overall; benefit in non-epithelioid subgroup.
- 2024Trial resultMARS 2MARS 2 reported
OS HR 1.
- 2024MilestoneBEAT-meso (ETOP 13-18)BEAT-meso misses OS; non-epithelioid subgroup benefits
A milestone in how this cancer is treated.
- 2024MilestoneMARS 2MARS 2: surgery worsens survival; pembrolizumab-chemotherapy approved (September)
A milestone in how this cancer is treated.
2023 · 2
2022 · 1
2021 · 1
October 2020 · 1
2020 · 3
- 2020Trial resultCheckMate 743CheckMate 743 reported
OS 18.
- 2020MilestoneCheckMate 743CheckMate 743: nivolumab-ipilimumab approved, first new first line in 16 years
A milestone in how this cancer is treated.
- 2020MilestoneMesotheliomaNivolumab-ipilimumab first line
A milestone in how this cancer is treated.
May 2019 · 1
2019 · 4
- 2019Trial resultLUME-MesoLUME-Meso reported
PFS HR 1.
- 2019Trial resultSTELLARSTELLAR reported
Median OS 18.
- 2019MilestoneLUME-MesoLUME-Meso fails; nintedanib abandoned in mesothelioma
A milestone in how this cancer is treated.
- 2019MilestoneSTELLARTTFields device approval (HDE) on STELLAR
A milestone in how this cancer is treated.
2016 · 2
2014 · 2
2011 · 1
2004 · 3
- 2004ApprovalPemetrexedPemetrexed approved in US
Unresectable pleural mesothelioma with cisplatin
- 2004MilestonePemetrexedPemetrexed approved: first mesothelioma drug
A milestone in how this cancer is treated.
- 2004MilestoneMesotheliomaPemetrexed-cisplatin approved
A milestone in how this cancer is treated.