What changed: Osteosarcoma

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Every dated change on the records linked to Osteosarcoma, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Approval2Trial result2Milestone7This record1

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September 2026 · 1

2026-09-08This recordOsteosarcoma
Facts on this page last checked
When this page itself was last checked or edited.

2019 · 1

2019MilestoneRegorafenib
Regorafenib (SARC024, REGOBONE) and cabozantinib (CABONE) show activity at relapse
A milestone in how this cancer is treated.

2016 · 3

2009 · 1

2009ApprovalMifamurtide
Mifamurtide approved in EU
High-grade resectable non-metastatic osteosarcoma after complete resection, with chemotherapy, ages 2-30

2008 · 1

2008MilestoneMifamurtide
INT-0133: mifamurtide improves overall survival; EU approval 2009
A milestone in how this cancer is treated.

1986 · 1

1986MilestoneOsteosarcoma
Randomised proof that adjuvant chemotherapy cures (Link, NEJM; MIOS)
A milestone in how this cancer is treated.

1979 · 1

1979MilestoneLimb-salvage surgery and endoprosthetic reconstruction
Rosen's T-10: neoadjuvant chemotherapy and limb salvage
A milestone in how this cancer is treated.

1972 · 1

1972MilestoneMethotrexate
High-dose methotrexate with leucovorin rescue (Jaffe) and adriamycin (Cortes) show activity
A milestone in how this cancer is treated.

1970 · 1

1970MilestoneOsteosarcoma
Amputation alone cures <20%; lung metastases the rule
A milestone in how this cancer is treated.

1953 · 1

1953ApprovalMethotrexate
Methotrexate approved in US
ALL, choriocarcinoma, and later osteosarcoma, breast, head and neck, lung, lymphoma, mycosis fungoides