Paediatric high-grade glioma (excluding diffuse midline glioma)

What changed: Paediatric high-grade glioma (excluding diffuse midline glioma)

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Every dated change on the records linked to Paediatric high-grade glioma (excluding diffuse midline glioma), newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

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September 2026 · 1

2026-09-17This recordPaediatric high-grade glioma (excluding diffuse midline glioma)
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When this page itself was last checked or edited.

2023 · 1

2023MilestoneDabrafenib + trametinib
Dabrafenib plus trametinib in BRAF V600E paediatric high-grade glioma
Hargrave and colleagues (JCO) report durable responses in the paediatric cohort.

2022 · 2

2021 · 1

2021MilestonePaediatric high-grade glioma (excluding diffuse midline glioma)
WHO 2021 defines four paediatric-type diffuse high-grade gliomas
A milestone in how this cancer is treated.

2018 · 1

2018MilestoneBevacizumab (glioblastoma use)
HERBY: bevacizumab adds nothing to radiotherapy and temozolomide
Grill and colleagues (JCO).

2012 · 1

2012MilestonePaediatric high-grade glioma (excluding diffuse midline glioma)
Histone H3 mutations discovered in paediatric glioma
Schwartzentruber and colleagues (Nature) and Wu and colleagues (Nature Genetics) find H3.3 K27M and G34 mutations.

1989 · 1

1989MilestonePaediatric high-grade glioma (excluding diffuse midline glioma)
CCG-943: chemotherapy adds to radiotherapy in childhood high-grade glioma
Sposto and colleagues, the first randomised evidence for adjuvant chemotherapy in children.