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drugsProductApproved2009🇯🇵🇦🇺

Bevacizumab (glioblastoma use)

A blood-vessel-blocking antibody that shrinks glioblastoma on scans and reduces swelling, but has never been shown to help patients live longer.

Accelerated approval for recurrent glioblastoma (2009, full 2017) on radiographic response. AVAglio and RTOG 0825 (2014): PFS gain in newly diagnosed disease without OS benefit; EORTC 26101 at recurrence: PFS but no OS benefit with lomustine. Valuable for steroid-sparing control of oedema and radiation necrosis. A case study in pseudo-response and the limits of imaging endpoints in glioma.

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Bevacizumab Fab bound to VEGF (PDB 1BJ1), backbone trace
RCSB PDB
Modality
Monoclonal antibody (anti-VEGF)
Mechanism
Neutralises VEGF-A; normalises vasculature and reduces contrast enhancement and oedema.
Brand / code
Avastin
Medicare
Part B (clinician-administered)

Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. Same drug and coding as bevacizumab; the glioblastoma indication is on label.

Commercial insurance
step therapy common

Preferred biosimilar usually required; some plans apply additional review for recurrent glioblastoma.

Assistance programmes

20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.

Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B) · FDA: Biosimilars. Not medical or financial advice; verify with your plan.

Not appraisedSearch NICE
Notes
Not licensed for glioblastoma in the EU or UK (EMA refused 2009); not funded on the NHS except via trials or individual funding requests.
NHS England
Not routinely funded

Sources: NICE search: bevacizumab for glioblastoma. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

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Approvals

RegionYearIndication
US2009Recurrent glioblastoma (accelerated; full approval 2017)

Trials

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ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
2390 studies19 recruiting84 Phase 220 Phase 3
Search “Bevacizumab” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Bevacizumab (glioblastoma use)
intervention: Bevacizumab
Open on ClinicalTrials.gov →

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Latest papers

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Literature trend1,405 papers in the last 12 months+10% vs prior 12How this is computed
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Bevacizumab" OR ABSTRACT:"Bevacizumab" OR TITLE:"glioblastoma use" OR ABSTRACT:"glioblastoma use" OR TITLE:"Avastin" OR ABSTRACT:"Avastin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Bevacizumab (glioblastoma use), not a curated reading list.

Connected

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